Answer the following questions as honestly as possible. Think about how you have been feeling over the previous month and how often you have been bothered by any of the following problems. Score the occurrence and frequency of each symptom on the following scale: never, sometimes, most of the time, all of the time or not applicable.

Give yourself the score of 0-3 depending on the frequency of your condition.
Symptoms Never (0) Sometimes (1) Most of the Time (2) All the Time (3)
Unexplained fevers, sweats, chills, or flushing
Unexplained weight change; loss or gain
Fatigue, tiredness
Unexplained hair loss
Swollen glands
Sore throat
Testicular or pelvic pain
Unexplained menstrual irregularity
Unexplained breast milk production; breast pain
Irritable bladder or bladder dysfunction
Sexual dysfunction or loss of libido
Upset stomach
Change in bowel function (constipation or diarrhea)
Chest pain or rib soreness
Shortness of breath or cough
Heart palpitations, pulse skips, heart block
History of a heart murmur or valve prolapse
Joint pain or swelling
Stiffness of the neck or back
Muscle pain or cramps
Twitching of the face or other muscles

Neck cracks or neck stiffness
Tingling, numbness, burning, or stabbing sensations
Facial paralysis (Bell’s palsy)
Eyes/vision: double, blurry
Ears/hearing: buzzing, ringing, ear pain
Increased motion sickness, vertigo
Lightheadedness, poor balance, difficulty walking
Confusion, difficulty thinking
Difficulty with concentration or reading
Forgetfulness, poor short-term memory
Disorientation: getting lost; going to wrong places
Difficulty with speech or writing
Mood swings, irritability, depression
Disturbed sleep: too much, too little, early awakening
Exaggerated symptoms or worse hangover from alcohol
Section 1 Score:
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If you rated a 3 for all of the following symptoms in section 1, give yourself an additional 5 points:
Forgetfulness, poor short-term memory
Tingling, numbness, burning or stabbing sensations
Distrubed sleep: too much, too little, early awakening
Section 2 Score:
Now please circle the points for each of the following statements you can agree with:
1. You have had a tick bite with no rash or flulike symptoms. 3 points
2. You have had a tick bite, an erythema migrans, or an undefined rash, 
followed by flulike symptoms. 5 points
3. You live in what is considered a Lyme-endemic area. 2 points
4. You have a family member who has been diagnosed with Lyme and/or 
other tick-borne infections. 1 point
5. You experience migratory muscle pain. 4 points
6. You experience migratory joint pain. 4 points
7. You experience tingling/burning/numbness that migrates and/or comes 
and goes. 4 points
8. You have received a prior diagnosis of chronic fatigue syndrome or 
fibromyalgia. 3 points
9. You have received a prior diagnosis of a specific autoimmune disorder (lupus, 
MS, or rheumatoid arthritis), or of a nonspecific autoimmune disorder. 3 points
10.  You have had a positive Lyme test, such as an immunofluorescent assay (IFA), ELISA, Western blot, PCR, lymphocyte transformation tests (LTT and/ 
or ELISPOT) and/or Borrelia culture). 5 points
Section 3 Score:
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1. Thinking about your overall physical health, for how many of the past thirty days was your physical health not good? _______Days
Award yourself the following points based on the total number of days:
0–5 days = 1 point
6–12 days = 2 points
13–20 days = 3 points
21–30 days = 4 points
2. Thinking about your overall mental health, for how many days during the past thirty days was your mental health not good? _____Days

Award yourself the following points based on the total number of days:
0–5 days = 1 point
6–12 days = 2 points 13–20 days = 3 points 21–30 days = 4 points Score:
Section 4 Score: 
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Record your total scores for each section below and add them together to achieve your Health Score –
Section 1 Score:
Section 2 Score:
Section 3 Score:
Section 4 Score:

If you scored: Below 25 Not Likely to Have Tick-Borne illness

If you scored: 25-44  Possible Tick-borne Illness

If you scored: 45-62  Likely to have Tick-borne Illness

If you scored: Above 63  Highly Likely to have Tick-born Illness


Empirical Validation of the Horowitz Multiple Systemic Infectious Disease Syndrome Questionnaire for Suspected Lyme Disease

Citera, Freeman,& Horowitz (under Review at PLoS One)


Lyme disease is spreading worldwide, with multiple Borrelia species causing a broad range of clinical symptoms mimicking other illnesses. Serological laboratory tests for Lyme are known to be insensitive and unreliable, due to the bacteria’s ability to avoid immune recognition. A validated screening questionnaire would be clinically useful for both providers and patients. Three studies evaluated the Horowitz Multiple Systemic Infectious Disease Syndrome (MSIDS) Questionnaire (HMQ). Study 1, examined factor analysis and the psychometric properties of the questionnaire (reliability, construct, divergent and predictive validity) among 537 individuals being treated for Lyme disease. Study 2 involved an online sample of 1142 participants, who self-identified as either healthy (N=360) or suffering from Lyme now (N=782) and who completed the HMQ along with an outdoor activity survey. We examined convergent validity among the components of the scale and evaluated discriminant validity with the Big 5 personality characteristics. The third study compared the patient sample from Study 1 with an online sample of 637 healthy individuals. The purpose was to see if the questionnaire could accurately distinguish between Lyme patients and healthy individuals. Factor analysis results identified six underlying latent dimensions; four of these overlapped with critical symptoms identified by Horowitz—Neuropathy, Cognitive Dysfunction, Muscular/Skeletal Pain, and Fatigue. The HMQ showed acceptable levels of internal reliability using Cronbach’s Coefficient alpha. HMQ scores exhibited evidence of convergent and divergent validity. Components of the HMQ correlated more highly with each other than with unrelated traits. The results consistently demonstrated that the HMQ accurately differentiated those with Lyme disease from healthy individuals. The results support the use of the HMQ as a valid, efficient screening tool for medical practitioners and as an aid to individuals that may need to seek treatment.